Women make up most Dr. Oz’s audience. Virtually all women would want to lose weight. That is a match made in heaven, a marketer’s dream. And Oz has never hesitated to exploit this fact to enhance audience share, playing fast and loose with sensationalized evidence as an alternative to giving his viewers science-based advice.
Garcinia cambogia extract (GCE) emanates from a tropical fruit from India and Southeast Asia. The active ingredient, where can garcinia cambogia be purchased, is considered to block fat and suppress the appetite.
Garcinia cambogia extract (GCE) comes from a tropical fruit from India and Southeast Asia. The active component, hydroxycitric acid (HCA), is considered to bar fat and suppress hunger.
Dr. Oz has promoted a number of weight loss supplements on his show. Raspberry ketones were presented as being a fat-busting miracle, then green coffee bean extract was touted as “magic,” “staggering,” and “unprecedented.” And now both those miracles have apparently been superseded by an even greater miracle: Garcinia cambogia extract.
Dr. Oz calls it “The newest, fastest fat buster.” Ways to lose weight without “spending every waking moment exercising and dieting.” “Triples your weight loss.” “The most exciting breakthrough in natural weight loss to date.” “The Holy Grail.” Oz claims that “Revolutionary new research says it may be the magic ingredient that allows you to lose weight without diet or exercise.”
All of that sounds too good to be true, in fact it is. Garcinia probably does work at some level to enhance weight loss, nevertheless the evidence doesn’t begin to justify such grandiose claims.
Garcinia cambogia extract (GCE) originates from a tropical fruit grown in India and Southeast Asia. The active ingredient has been identified: hydroxycitric acid (HCA). It is said to block fat and suppress hunger. It inhibits an integral enzyme, citrate lyase, the body demands to produce fat from carbohydrates. It suppresses appetite by increasing serotonin levels; low serotonin levels are associated with depression and emotional or reactive eating.
It allegedly decreases belly fat, suppresses appetite, controls emotional eating, and changes body composition by increasing lean muscle. It doesn’t just produce weight loss, but it really improves overall health. It is stated to decrease cholesterol, LDL, and triglycerides by 10-30% as well as to raise levels of the “good cholesterol” HDL.
An independent analysis found out that some brands contain much less active ingredient than claimed. Consumers are advised to look for a minimum of 50% GCE with potassium however with no fillers, binders, or artificial ingredients.
It needs to be taken on empty stomach 30-60 minutes before dinner. Results increase with dosage, but doses over 3 000 mg a day needs to be cleared with your doctor.
Dr. Oz recommends a dose of 500-1000 mg of forskolin 250 mg reviews before each meal. (Some experts believe the potassium salt is far more effective than other formulations.) He says to not carry it in case you are pregnant or breastfeeding, or for those who have Alzheimer’s disease or other forms of dementia, since it can worsen dementia. If you have diabetes, it can cause hypoglycemia, and when you are on a statin, it might increase the danger of harmful adverse reactions like rhabdomyolysis or muscle degradation.
Oz contradicts himself: he suggests that it can produce weight loss without diet or exercise, yet he clearly recommends it be used as well as exercise and effectively portioned meals.
The garcinia evidence
With Dr. Oz’s track record, I found myself not willing to easily accept his word for that wonders of Garcinia. I traveled to PubMed, where a look for hydroxycitric acid brought up 64 articles. Some were irrelevant, along with the relevant ones included plenty of animal studies as well as a smaller number of human studies with inconsistent results.
Guinea pigs on the high cholesterol diet who have been given some other Garcinia species (atriviridis) had an inclination to decrease lipid composition levels and fat deposition in devypky30 aorta. HCA caused congenital defects in rats. Another rat study learned that it decreased body weight gain and visceral fat accumulation by reduction of food consumption but had no lasting beneficial effects on hypertriglyceridemia and hyperinsulinemia. An additional rat study showed that it suppressed excess fat accumulation but was toxic on the testes.
In order to make sense of your inconsistent results, Onakpoya et al. did a systematic article on the published randomized controlled trials (RCTs) as of 2011. Their analysis found a tiny, statistically significant difference in weight loss (1.75 kg vs .88 kg, lower than 2 pounds). They commented the studies all had methodological weaknesses, so these results may be on account of GIGO (garbage in/garbage out). The two studies with the best methodology found no statistically significant difference from placebo. Adverse events were two times as common with Garcinia (headache, nausea, upper respiratory and gastrointestinal symptoms). The authors concluded:
Evidence from RCTs shows that Garcinia extracts/HCA generate weight loss on the short term. However, the magnitude with this effect is small, has stopped being statistically significant when only rigorous RCTs are thought, along with its clinical relevance seems questionable.
Oz featured an individual testimonial in the show from your woman who had lost 10 pounds in 4 months. She started noticing results after a week; she reported that her sugar cravings were decreased, she had more energy, and she went down a dress size from 10 to 8. She had no adverse reactions. Says she was at a plateau and wanted a jump-start.
At this stage, I don’t think we can easily reliably say whether forskolin extract carries a clinically relevant advantage on simple calorie reduction and physical activity. It looks to be safe, and it may have a role in assisting patients lose weight by assisting motivation and enlisting placebo effects.
Dr. Oz’s popularity is enduring, but diet fads aren’t. I confidently expect another “miracle” to supplant Garcinia inside the Land of Oz from the not-too-distant future.